The Association between Ocular Problems and Serum Testosterone, Prolactin and Thyroglobulin Concentrations in Delayed Phase of Sulfur Mustard Exposure

Authors

  • Hassan Ghasemi Immunoregulation Research Center, Shahed University, Tehran, I.R. Iran | Dept. of Ophthalmology, Shahed University, Tehran, I.R. Iran
  • Nayere Askari Dept. of biology, Faculty of Basic Sciences, Shahid Bahonar University of Kerman, Kerman, I.R Iran
  • Soghrat Faghihzadeh Dept. of Biostatistics and Social Medicine, Zanjan University of Medical Sciences, Zanjan, I.R. Iran
Abstract:

Background and objective Aside from direct toxic effects, Sulfur Mustard (SM) induced serum hormone abnormalities may aggravate ocular complaints, including Ocular Surface Discomfort (OSD) (burning, itching, and redness), dry eye sensation, photophobia, blurred vision, foreign body sensation, and pain. The aim of the current study was to investigate the possible association of ocular complaints with serum hormone concentrations in chronic phase of Sulfur Mustard (SM) exposure. Methods:As a part of Sardasht Iran Cohort Study (SICS), 372 SM-exposed patients and 128 non-exposed participants were enrolled. Ocular complaints and ocular surface biomicroscopic conditions and serum hormones were compared. Results:The exposed with tearing group had significantly higher mean serum levels of testosterone and prolactin (ng/mL) than controls (5.75 vs. 4.75, P=0.031; 11.71 vs. 8.42, P=0.009). The exposed with OSD group had significantly higher mean serum levels of prolactin than controls (12.48 vs. 6.90, P=0.002). The exposed with photophobia group had significantly higher mean serum levels of testosterone than the matched exposed (6.25 vs. 5.65, P=0.013). The exposed with blurred vision group had significantly higher mean serum levels of Thyroglobulin (Tg) (ng/mL) than the matched exposed (65.73 vs. 32.6, P=0.003). Conclusion: Higher mean serum levels of testosterone (in exposed with tearing and photophobia) and prolactin (in exposed with tearing and OSD) may play protective roles against SM effects. Higher mean serum levels of Tg may deteriorate the tear film integrity and optical surface, which causes blurred vision. In the chronic phase of SM toxicity, some ocular surface problems are associated with alterations in the serum concentrations of testosterone, prolactin, and Tg.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Association of Sulfur Mustard-induced Ocular Problems with Serum and Blood Biochemical Parameters Changes

Background and objective:Many biochemical features of sulfur mustard (SM) intoxication remained unknown. So far, the direct association between biochemical parameter changes and ocular problems in patients exposed to SM is not evaluated.The current study aimed at evaluating the associations between the ocular findings in patients with SM intoxication and the changes of...

full text

the relationship between learners critical thinking ability and their performance in the reading sections of the tofel and ielts test

the study reflected in this thesis aims at finding out relationships between critical thinking (ct), and the reading sections of tofel and ielts tests. the study tries to find any relationships between the ct ability of students and their performance on reading tests of tofel and academic ielts. however, no research has ever been conducted to investigate the relationship between ct and the read...

15 صفحه اول

the relationship between academic self-concept and academic achievement in english and general subjects of the students of high school

according to research, academic self-concept and academic achievement are mutually interdependent. in the present study, the aim was to determine the relationship between the academic self-concept and the academic achievement of students in english as a foreign language and general subjects. the participants were 320 students studying in 4th grade of high school in three cities of noor, nowshah...

SERUM CONCENTRATIONS OF VARIOUS HORMONES FOLLOWING EXPOSURE TO CHEMICAL WEAPONS CONTAINING SULFUR MUSTARD

Serum concentration of FSH, LH, testosterone, prolactin, ACTH, cortisol, TSH, T4, T3 and resin T3 uptake were measured in 146 men who were exposed to vesicants used by the Iraqi regime a few days t04 weeks prior to testing. Clinical and laboratory findings had confirmed the use of mustard gas. Mean serum concentrations of FSH, LH, TSH and prolactin were not significantly different from no...

full text

Serum Concentrations of Various Hormones Following Exposure to Chemical Weapons Containing Sulfur Mustard

Serum concentration of FSH, LH, testosterone, prolactin,ACTH,cortisol, TSH, T ,T and resin Tuptake were measured in 146 men who were exposed to vesicants used by Iraqi regime, few days to 4 weeks prior to test'ing, Clinical and laboratory findings had confirmed that mustards had been used. Mean serum concentrations of FSH, LH, TSH and prolactin were not signi­ficantly different from normals. Fr...

full text

Pathogenesis of acute and delayed corneal lesions after ocular exposure to sulfur mustard vapor.

PURPOSE Sulfur mustard (SM) exposure results in dose-dependent morbidities caused by cytotoxicity and vesication. Although lesions resulting from ocular exposure often resolve clinically, an idiopathic delayed mustard gas keratopathy (MGK) can develop after a moderate or severe exposure. Sequelae include persistent keratitis, recurring epithelial lesions, corneal neovascularization, and corneal...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 13  issue 1

pages  63- 70

publication date 2018-01-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023